Dr. Bipasha Bose

Affiliation : Associate Professor (Senior), Stem Cells an Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, India

Title of the Talk/Lab :Pluripotent stem cells-why it is important to characterize at all the steps of differentiation using flow cytometry

Dr Bipasha Bose obtained her PhD from the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India in 2004. Thereafter she co-worked in the group in Reliance Life Sciences Pvt Ltd, Navi Mumbai as a Research Scientist for deriving the human Embryonic Stem Cell (ESC) line for the first time in Indian sub-continent (2004-2008), and then as a project lead for differentiating human ESC into functional pancreatic β cells. Eventually Dr Bose moved back to academia and worked for her first post-doctoral in the Stem Cell Institute, Catholic University of Leuven, Belgium (2008-2009) wherein she differentiated human pluripotent stem cells into endodermal lineages: liver and kidney. Her second post-doctoral work as a senior fellow (2009-2014) was in the School of Biological Sciences, Nanyang Technological University Singapore working on different aspects of muscle stem cells and deriving culture induced pluripotent stem cells without growth factors or small molecules.

Dr Bose started in her current place of work in late 2014 and was involved in setting up of the Stem Cells and Regenerative Medicine Centre, securing governmental funding from various agencies. Currently, Dr Bose has a cumulative funding of INR 1.3 Crore over last 5 years from Indian funding agencies in the role of a Principal Investigator. Her current work includes differentiation of human pluripotent stem cells into pancreatic β cells using bioactive lipids, ocular stem cell damages from ultraviolet radiation and its mitigation using marine bioactives, effect of natural high background radiation on lung stem cells, targeting breast and colon cancer stem cell organoids and molecular effects of fluoride on skeletal muscle stem cells. Dr Bose has 40 articles indexed in PubMed https://pubmed.ncbi.nlm.nih.gov/?term=Bipasha+Bose&sort=pubdate), 5 book chapters and 2 patents to her credit

Lecture:

Relevant Literature:

1. Chaudhury, D., Sen, U., Biswas, S., Shenoy P, S., & Bose, B*. (2022). Assessment of Threshold Dose of Thoron Inhalation and Its Biological Effects by Mimicking the Radiation Doses in Monazite Placer Deposits Corresponding to the Normal, Medium and Very High Natural Background Radiation Areas. Biological trace element research, 10.1007/s12011-022-03398-x. Advance online publication. https://doi.org/10.1007/s12011-022-03398-x
2. Nagendra, A. H., Najar, M. A., Bose, B*, & Shenoy, P. S*. (2022). High concentration of sodium fluoride in drinking water induce hypertrophy versus atrophy in mouse skeletal muscle via modulation of sarcomeric proteins. Journal of hazardous materials, 432, 128654. https://doi.org/10.1016/j.jhazmat.2022.128654
3. Sen, U., Chaudhury, D., Shenoy P, S., & Bose, B*. (2021). Differential sensitivities of triple-negative breast cancer stem cell towards various doses of vitamin C: An insight into the internal antioxidant systems. Journal of cellular biochemistry, 122(3-4), 349–366. https://doi.org/10.1002/jcb.29863
4. Bose B*. (2021). Induced Pluripotent Stem Cells (iPSCs) Derived 3D Human Lung Organoids from Different Ethnicities to Understand the SARS-CoV2 Severity/Infectivity Percentage. Stem cell reviews and reports, 17(1), 293–295. https://doi.org/10.1007/s12015-020-09989-2
5. Kapoor, S., Subba, P., Shenoy P, S., & Bose, B*. (2021). Sca1⁺Progenitor Cells (Ex vivo) Exhibits Differential Proteomic Signatures From the Culture Adapted Sca1⁺ Cells (In vitro), Both Isolated From Murine Skeletal Muscle Tissue. Stem cell reviews and reports, 17(5), 1754–1767. https://doi.org/10.1007/s12015-021-10134-w
6. Bose, B*., Kapoor, S., Sen, U., Nihad As, M., Chaudhury, D., & Shenoy P, S. (2020). Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage. Journal of visualized experiments : JoVE, (156), 10.3791/59924. https://doi.org/10.3791/59924

*Corresponding author